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Alex Dean
Previous research has explored occupational activity of breast cancer survivors but has not examined the influence of occupational level on symptoms prospectively. The purpose of this study was to examine the relationship between occupational classification and changes in mood and symptom burden for postmenopausal breast cancer survivors during… (Show more)
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Alex Dean
Electrospun fibers show potential as a topical delivery system for vaginal microbicides. Previous reports have demonstrated delivery of anti-HIV and anti-STI (sexually transmitted infection) agents from fibers formulated using hydrophilic, hydrophobic, or pH-responsive polymers that result in rapid, prolonged, or stimuli-responsive release,… (Show more)
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Alex Dean
Felodipine(Fel) (ethylmethyl-4-(2,3-dichlorophenyl)-1,4-dihy-dro-2,6-dimethyl-3,5-pyridinedicar boxylate) has been chosen as the subject of this study. Being a calcium channel blocker, felodipine is widely used for treating hypertension. The choice of this compound can be explained by the following reasons.
in Science
Alex Dean
A primary goal of asthma management is the reduction of exacerbation risk. We assessed the occurrence of oral corticosteroid-requiring exacerbations (OCS exacerbations) with long-term fluticasone/formoterol therapy, and compared it with the occurrence of similar events reported with other inhaled corticosteroid/long acting β2-agonist (ICS/LABA)… (Show more)
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Alex Dean
Deoxynivalenol inhibits protein biosynthesis, binds to peptidyl transferase, and inhibits the synthesis of RNA and DNA, contributing to immunotoxicity. Hence, it's used as potent protein synthesis inhibitor. Besides,it exhibits cytotoxic activity in vivo via the ribotoxic stress responseand induces p38-mediated gene expression and apoptosis in… (Show more)
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Alex Dean
Purmorphamine, a 2,6,9-trisubstituted purine compound, was identified as a potent osteogenic differentiation inducing molecule through a high throughput chemical screen in C3H10T1/2 cells. Expression profiling of cells treated with purmorphamine in conjunction with systematic pathway analysis was used to reveal that the Hedgehog/Hh signaling… (Show more)
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Alex Dean
Fidaxomicin is an antibiotic that belongs to the class of the macrocyclics and is indicated for the treatment of CDI. In clinical trials, fidaxomicin, when compared to vancomycin, was non-inferior for the clinical cure of patients with CDI and superior for the reduction of recurrence rates, with a greater sustained response after 30 days. Of the… (Show more)
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Alex Dean
In my previous article, I have explored in brief the therapeutic functions of two inhibitors, nepicastat HCl to treat posttraumatic stress disorder and setipiprant to treat allergic disorders. However, besides these two, actually there are many other inhibitors that has similar medical functions. Today, we will discuss inhibitor fluticasone… (Show more)
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